Clinical Trial

Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

Study acronym: DEKS
Enrolling by Invitation
View on ClinicalTrials.gov →
Summary
This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK). Study eyes are assigned to receive either a cornea from a donor without diabetes or a cornea from a donor with diabetes in a masked fashion.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-10-13; most recent amendment 2026-02-26.
Status change: Recruiting → Enrolling by Invitation 2026-02-26
Status change: Not Yet Recruiting → Recruiting 2025-12-11
Trial Details
NCT Number NCT07217249
Lead Sponsor Case Western Reserve University
Collaborators: National Eye Institute (NEI)
Conditions Fuchs Endothelial Corneal Dystrophy, Corneal Endothelial Decompensation
Enrollment 570 participants
Start Date 2025-12-03
Primary Completion 2029-12-30 (estimated)
Study Completion 2030-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-02-27