NotablePrimary completion pushed from Sep 29, 2026 to Sep 29, 2027
MinorInterventions: A/Mallard/Ohio-99/MM4/1989 H10N7 (Biological) to A/Mallard/Ohio-99/MM4/1989 H10N7 (Biological)
Eligibility criteria expanded, about 63 words
Study description expanded, about 17 words
Publications: details revised at 3 of 3 entries
MinorRe-verified, no change to tracked fieldsv123
MinorStart date changed from estimate of Apr 28, 2026 to Apr 21, 2026v122
MinorStart date: Apr 27, 2026 to Apr 28, 2026v121
Show 45 earlier versionsHide 45 earlier versions
MinorStart date: Apr 26, 2026 to Apr 27, 2026v120
MinorStart date: Apr 23, 2026 to Apr 26, 2026v119
MinorStart date: Apr 22, 2026 to Apr 23, 2026v118
MinorStart date: Apr 21, 2026 to Apr 22, 2026v117
MinorStart date: Apr 20, 2026 to Apr 21, 2026v116
MinorStart date: Apr 19, 2026 to Apr 20, 2026v115
MinorStart date: Apr 16, 2026 to Apr 19, 2026v114
MinorStart date: Apr 15, 2026 to Apr 16, 2026v113
MinorStart date: Apr 14, 2026 to Apr 15, 2026v112
MinorStart date: Apr 13, 2026 to Apr 14, 2026v111
MinorStart date: Apr 12, 2026 to Apr 13, 2026v110
MinorStart date: Apr 9, 2026 to Apr 12, 2026v109
MinorStart date: Apr 8, 2026 to Apr 9, 2026v108
MinorStart date: Apr 7, 2026 to Apr 8, 2026v107
MinorStart date: Apr 6, 2026 to Apr 7, 2026v106
MinorStart date: Apr 5, 2026 to Apr 6, 2026v105
MinorStart date: Apr 2, 2026 to Apr 5, 2026v104
MinorStart date: Apr 1, 2026 to Apr 2, 2026v103
MinorStart date: Mar 31, 2026 to Apr 1, 2026v102
MinorStart date: Mar 30, 2026 to Mar 31, 2026v101
MinorStart date: Mar 29, 2026 to Mar 30, 2026v100
MinorStart date: Mar 26, 2026 to Mar 29, 2026v99
MinorStart date: Mar 25, 2026 to Mar 26, 2026v98
MinorStart date: Mar 24, 2026 to Mar 25, 2026v97
MinorStart date: Mar 23, 2026 to Mar 24, 2026v96
MinorStart date: Mar 22, 2026 to Mar 23, 2026v95
MinorStart date: Mar 19, 2026 to Mar 22, 2026v94
MinorStart date: Mar 18, 2026 to Mar 19, 2026v93
MinorStart date: Mar 17, 2026 to Mar 18, 2026v92
MinorStart date: Mar 16, 2026 to Mar 17, 2026v91
MinorStart date: Mar 15, 2026 to Mar 16, 2026v90
MinorStart date: Mar 12, 2026 to Mar 15, 2026v89
MinorStart date: Mar 11, 2026 to Mar 12, 2026v88
MinorStart date: Mar 10, 2026 to Mar 11, 2026v87
MinorStart date: Mar 9, 2026 to Mar 10, 2026v86
MinorStart date: Mar 8, 2026 to Mar 9, 2026v85
MinorStart date: Mar 5, 2026 to Mar 8, 2026v84
MinorStart date: Mar 4, 2026 to Mar 5, 2026v83
MinorStart date: Mar 3, 2026 to Mar 4, 2026v82
MinorStart date: Mar 2, 2026 to Mar 3, 2026v81
MinorStart date: Mar 1, 2026 to Mar 2, 2026v80
MinorStart date: Feb 26, 2026 to Mar 1, 2026v79
MinorStart date: Feb 25, 2026 to Feb 26, 2026v78
MinorStart date: Feb 24, 2026 to Feb 25, 2026v77
MinorStart date: Feb 23, 2026 to Feb 24, 2026v76
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
Influenza (flu) is a virus that can infect humans and animals. In humans, the flu can cause mild symptoms such as fever, cough, sore throat, runny nose, muscle aches, headaches, and fatigue. It can also cause sinus infections or pneumonia. Some flu strains, such as H5N1 and H7N9, which come from birds, can lead to more severe symptoms or death. Others, like H10N7, also come from birds but usually cause mild symptoms. Researchers want to study bird flu in humans to help develop new flu vaccines and treatments.
Objective:
To learn more about how bird flu viruses infect humans.
Eligibility:
Healthy people aged 18 to 55 years who were infected with the H10N7 bird flu strain as part of a previous study.
Design:
Participants who were infected with H10N7 in a previous study will be infected again with the same virus. The virus will be sprayed into their nostrils.
Participants will stay in the hospital for at least 9 days. They will stay in an isolation unit. No outside visitors will be allowed.
During their stay, participants will provide blood, urine, and nasal fluid samples. They will have tests of their heart and lung function. They will complete questionnaires about their symptoms.
Participants will remain in the hospital until they test negative for the flu 2 days in a row. They will continue to complete questionnaires about their symptoms for 2 weeks after they were infected with the virus.
Participants will have 2 follow-up visits, at 5 weeks and 9 weeks after they were infected. They will have a physical exam and provide samples of blood and nasal fluids. They will have a test of their heart function.
...