Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1

In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain activity as measured by fMRI and demonstrate its ability to focally stimulate deep brain regions without affecting overlying cortex. In the longer term, investigators aim to use these data to resolve longstanding debates about the function of deeper brain regions and lay the foundation for future clinical applications of TI for treating addiction, Obsessive-Compulsive Disorder (OCD), Parkinson's disease, and other disorders involving deep brain dysfunction. The grant supports 2 distinct aims, each of which will be evaluated through a series of independent studies.

NCT Number	NCT07215299
Lead Sponsor	Indiana University Collaborators: National Institute of Mental Health (NIMH)
Conditions	Healthy Volunteers
Enrollment	30 participants
Start Date	2025-11-12
Primary Completion	2026-02-02 (estimated)
Study Completion	2026-02-02 (estimated)
Updated on ClinicalTrials.gov	2026-08-03