Acoustic Resonance Therapy for Treating Empty Nose Syndrome

This study is to determine whether Acoustic Resonance Therapy (ART), an FDA-approved treatment for standard nasal obstruction, may be helpful in mitigating the debilitating symptoms of Empty Nose Syndrome (ENS), which includes an alternative form of nasal obstruction. ART is a non-invasive treatment that uses sound vibrations to improve nasal congestion and other sinus symptoms. ART works by delivering specific frequencies of sound to the sinonasal cavities (nose and sinuses). These vibrations cause the tissues in the sinuses to resonate, which can help break up mucus and clear blockages, reduce inflammation, and improve airflow.

NCT Number	NCT07215013
Lead Sponsor	Stanford University Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Empty Nose Syndrome, Nasal Obstruction
Enrollment	40 participants
Start Date	2028-07
Primary Completion	2030-07 (estimated)
Study Completion	2030-07 (estimated)
Updated on ClinicalTrials.gov	2025-10-10