Clinical Trial

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

Completed
View on ClinicalTrials.gov →
Summary
Smoking is a prominent public health issue. Traditional nicotine replacement therapy suffers from being a poor substitute for cigarettes. Novel tobacco products, such as nicotine pouches, show promise as potential low-harm substitutes. Investigators wish to assess the substitutability of cigarettes for nicotine pouches at different dosages and price points. This study will consist of 4000 screened participants online on the crowdsourcing software Prolific, with roughly 400 eligible participants. This study will include the use of an electronic tobacco marketplace.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2025-10-06; most recent amendment 2026-04-27.
Status change: Recruiting → Completed 2026-01-16
Status change: Not Yet Recruiting → Recruiting 2025-12-04
Trial Details
NCT Number NCT07213947
Lead Sponsor William Middleton
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Tobacco Use, Nicotine Pouch Self-Administration
Enrollment 1,360 participants
Start Date 2025-12-04
Primary Completion 2026-01-02 (estimated)
Study Completion 2026-01-02 (estimated)
Updated on ClinicalTrials.gov 2026-05-01