Clinical Trial

High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy

Study acronym: DEXTER
Recruiting Phase 2/3
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Summary
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-10-01.
Trial Details
NCT Number NCT07213375
Lead Sponsor Rigshospitalet, Denmark
Conditions Analgetic, Lung Cancer (NSCLC), Video Assisted Thoracic Surgery (VATS), Glucocorticoid
Enrollment 80 participants
Start Date 2025-09-01
Primary Completion 2026-10 (estimated)
Study Completion 2026-11 (estimated)
Updated on ClinicalTrials.gov 2026-01-07