Clinical Trial

Synthetic Angiotensin II/Giapreza in Pediatric Patients With Refractory Hypotension

Enrolling by Invitation Phase 4
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Summary
The goal of this clinical trial is to determine the safety and efficacy of Angiotensin-II in the treatment of pediatric patients in fluid refractory vasodilatory shock. The main questions it aims to answer are: * To evaluate the change in blood pressure or reduction of vasoactive requirements (norepinephrine equivalent dosing) after initiating Angiotensin II * To establish the safety and tolerability of Angiotensin-II in pediatric patients Participants will receive Angiotensin-II in addition to standard of care therapy for vasodilatory shock. * The study team will then monitor the patient's vital signs, blood work, and for any potential side effects from the drug. * An ultrasound will be performed to look at blood flow through the kidney in the setting of vasodilatory shock. * A follow up phone call to check in with the patient will be performed 28 days after enrollment.
Trial Details
NCT Number NCT07212686
Lead Sponsor Todd Sweberg
Collaborators: Innoviva Specialty Therapeutics
Conditions Vasodilatory Shock
Enrollment 30 participants
Start Date 2025-09-09
Primary Completion 2030-06 (estimated)
Study Completion 2030-06 (estimated)
Updated on ClinicalTrials.gov 2025-10-08