Clinical Trial

Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression

Study acronym: NACC-D
Recruiting
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Summary
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have not tolerated or responded to antidepressant medications. The study will evaluate whether accelerated dTMS administered over 5 consecutive days is safe and well-tolerated in this population, and whether it produces greater reductions in depressive symptoms compared to placebo stimulation.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-09-30; most recent amendment 2025-10-27.
Trial Details
NCT Number NCT07212465
Lead Sponsor Rotman Research Institute at Baycrest
Conditions Major Depressive Disorder (MDD)
Enrollment 24 participants
Start Date 2025-07-21
Primary Completion 2027-01-01 (estimated)
Study Completion 2027-02-15 (estimated)
Updated on ClinicalTrials.gov 2025-10-28