Infant Microbiota Restoration With Maternal Microbes

The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants. The main question it aims to answer is: Do maternally derived strains of bacteria perform better than commercially available probiotic strains in restoring the gut microbiota of C-section born infants? Researchers will compare the gut microbiota of treated infants to that of untreated C-section born infants and untreated vaginally born infants to see if the bacterial treatments cause the microbiota to resemble that of vaginally born infants. Participants will be given a bacterial product orally once daily for either one or four weeks and be asked to collect faecal, urine and saliva samples.

NCT Number	NCT07212361
Lead Sponsor	University of Helsinki Collaborators: Helsinki University Central Hospital
Conditions	Infant, Newborn, Gut -Microbiota, Gut Dysbiosis, Cesarean Delivery Affecting Newborn, Cesarean Section, Vaginal Delivery, Gastrointestinal Microbiota, Microbiota, Cesarean Section, Probiotics, Dysbiosis +7 more
Enrollment	100 participants
Start Date	2025-07-17
Primary Completion	2035-12-31 (estimated)
Study Completion	2035-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-10-08