Clinical Trial

Topical Imiquimod Treatment of Oral Dysplasia

Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous change in the mouth). The main questions it aims to answer are: 1. Does imiquimod help to make the lesions smaller and make the abnormal cell changes less severe? 2. How can we make this treatment safer and more feasible? Participants will apply topical imiquimod cream to treat the oral dysplasia and receive two follow-up biopsies after the treatment.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-09-29.
Trial Details
NCT Number NCT07210775
Lead Sponsor University of Southern California
Conditions Oral Dysplasia, Leukoplakia Oral, Leukoplakia
Enrollment 20 participants
Start Date 2025-10-01
Primary Completion 2027-10-01 (estimated)
Study Completion 2027-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-04