Clinical Trial

Radiotherapy 12Gy in 6 Fractions For Orbital Lymphoma

Not Yet Recruiting
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Summary
Current standard RT doses (24-25Gy) provide excellent disease control for patients with indolent B-cell orbital lymphoma, but can cause significant late toxicities. Ultra-low dose RT (4Gy in 2 fractions) has minimal toxicity but lower disease control, requiring intensive follow-up to salvage persistent tumors. Some centers are moving towards this dose as the new standard. A recent study using 12Gy in 4 fractions to any body site showed early data suggesting high disease control rates with minimal toxicity. This study assesses 12Gy in 6 fractions, aiming to enhance disease control over 4Gy while reducing toxicity compared to 24Gy.
Trial Details
NCT Number NCT07210749
Lead Sponsor British Columbia Cancer Agency
Conditions Orbital Lymphoma
Enrollment 36 participants
Start Date 2025-11-01
Primary Completion 2035-08-31 (estimated)
Study Completion 2036-08-31 (estimated)
Updated on ClinicalTrials.gov 2025-10-07