Additional Effects of Neural Mobilization on Pain, Balance and Quality of Life in Diabetic Neuropathy

Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, affecting up to 50% of patients and causing pain, numbness, and balance impairments, which increase the risk of falls, ulcers, and reduced quality of life. Current treatments mainly manage symptoms, highlighting the need for adjunctive approaches. This randomized controlled trial will evaluate the additional effects of Neural Mobilization (NM) on pain, balance, and quality of life in DPN. Thirty-two patients with type 2 diabetes and DPN will be recruited at Fauji Foundation Hospital and screened using the Michigan Neuropathy Screening Instrument (MNSI). Participants will be randomized into two groups: (1) NM plus Balance Training with standard care and (2) Balance Training alone, each for six weeks (two 30-minute sessions/week). Pain will be assessed using the Numeric Pain Rating Scale (NPRS), balance using the Berg Balance Scale, and quality of life using the Norfolk QOL-DN questionnaire. Outcome measures will be recorded at baseline and post-intervention. Ethical approval will be obtained from FUMC ERC, and data will be analyzed using SPSS v.22.

NCT Number	NCT07210203
Lead Sponsor	Foundation University Islamabad
Conditions	Diabetic Neuropathy, Postural Balance, Pain
Enrollment	32 participants
Start Date	2024-09-13
Primary Completion	2025-12-10 (estimated)
Study Completion	2026-01-10 (estimated)
Updated on ClinicalTrials.gov	2025-10-07