Clinical Trial

Restructuring the Alpha-Gamma Code in Aging Vision

Recruiting Early Phase 1
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Summary
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-09-27.
Status change: Not Yet Recruiting → Recruiting 2026-07-14
Trial Details
NCT Number NCT07208318
Lead Sponsor Boston University Charles River Campus
Conditions Aging, Visual Perception, Noninvasive Brain Stimulation
Enrollment 240 participants
Start Date 2026-04-02
Primary Completion 2030-08-31 (estimated)
Study Completion 2030-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-16