Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD

The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is: is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test. Participants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.

NCT Number	NCT07207577
Lead Sponsor	Centre Hospitalier Metropole Savoie Collaborators: Université Savoie Mont Blanc, Laboratoire de Psychologie et NeuroCognition (LPNC), Université Grenoble Alpes
Conditions	Beta Thalassemia Transfusion Dependent
Enrollment	36 participants
Start Date	2025-09-04
Primary Completion	2028-10 (estimated)
Study Completion	2028-10 (estimated)
Updated on ClinicalTrials.gov	2025-10-06