Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes

Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes The goal of this clinical trial is to evaluate of the involvement of Neutrophil extracellular traps in the evolution of hepatocellular cancer. The main questions it aims to answer are: * How does the type of anesthesia used in hepatobiliary oncological surgery influence postoperative evolution and the immune response? * How does the type of anesthesia, TIVA versus inhalational influence the generation of neutrophil extracellular traps (NETs)? Researchers will compare the evolution of the patients assigned to 4 study groups depending on the anesthetic intervention performed. Participants will: * will be evaluated pre and postanesthesia, blood samples will be collected for analysis of the inflammatory response * will be followed up one year for establishing the outcome

NCT Number	NCT07207304
Lead Sponsor	Iuliu Hatieganu University of Medicine and Pharmacy
Conditions	Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia, Lidocaine Infusion
Enrollment	153 participants
Start Date	2022-02-03
Primary Completion	2023-03-23 (estimated)
Study Completion	2024-06-03 (estimated)
Updated on ClinicalTrials.gov	2026-06-23