A Physical Activity Program for People With Heart Failure

STEP-IN is a research study that examines the effects of a physical activity program designed to increase the daily steps and cadence of patients with heart failure, compared to standard medical care, on functional capacity and other markers related to heart and brain health. The primary hypothesis is that participating in the physical activity program for 9 months will improve functional capacity, the primary clinical measure, significantly more than receiving only the standard medical care in people with heart failure. It is also hypothesized that the physical activity program will have positive effects on symptoms and limitations related to heart failure, inflammation, as well as heart and brain health.

NCT Number	NCT07204834
Lead Sponsor	Universidad de Granada Collaborators: University Hospital Virgen de las Nieves, Hospital Universitario Clínico San Cecilio, Hospital Santa Ana de Motril, Mind, Brain and Behaviour Research Centre (CIMCYC), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Department of Medical BioSciences, Exercise Physiology ResearchGroup, Radboud University Medical Center, Nijmegen, The Netherlands, Instituto de Investigación Biosanitaria IBS Granada
Conditions	Heart Failure
Enrollment	200 participants
Start Date	2025-10-08
Primary Completion	2028-09 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-11-18