Visual and Refractive Outcomes Following Stream Light Photorefractive Keratectomy (55μm Epithelial Removal) Versus Conventional Photorefractive Keratectomy

Photorefractive keratectomy (PRK) is a well-established corneal refractive surgery that involves epithelial removal followed by stromal ablation to correct myopia, hyperopia, and astigmatism. The method of epithelial removal in PRK significantly impacts healing, pain levels, and visual outcomes. Trans-epithelial PRK (StreamLight) performed on the EX500 excimer laser platform removes the epithelium and reshapes the corneal stroma in a single laser-guided step, potentially reducing tissue manipulation and enhancing epithelial healing. In contrast, manual epithelial removal PRK involves mechanical debridement, with epithelial removal depth being manually controlled. The variability of epithelial thickness in StreamLight PRK may influence visual outcomes, whereas in manual PRK, a fixed epithelial removal depth of 55 microns provides a standardized approach.

NCT Number	NCT07203976
Lead Sponsor	Assiut University
Conditions	Photorefractive Keratectomy
Enrollment	100 participants
Start Date	2025-05-03
Primary Completion	2026-02 (estimated)
Study Completion	2026-05 (estimated)
Updated on ClinicalTrials.gov	2025-10-02