Chinese Real-world Study of Treatment of Vestibular Migraine

Vestibular migraine is a phenotype of migraine, characterized by more prominent vertigo symptoms compared to headache. Treatments for VM are mainly divided into two categories: acute treatment and preventive treatment. Acute treatment aims to reduce the severity and duration of a single episode, while preventive treatment aims to decrease the frequency, severity, and duration of attacks. Current acute treatments are primarily divided into pain relief and anti-dizziness, with specific drugs such as triptans and ergots being applicable for pain relief, but only betahistine has weak evidence for anti-dizziness, and relevant clinical evidence is very scarce. Preventive treatment mainly refers to migraine preventive treatments, with recommended medications including traditional drugs like topiramate, flunarizine, propranolol, etc., but the efficacy and safety of these drugs are limited. CGRP-targeted drugs are believed to play a role in the preventive treatment of VM, and there are related literature reports, but most are small-sample studies or retrospective studies. This study aims to explore the real-world efficacy of CGRP-targeted drugs in the acute and preventive treatment of VM through a prospective real-world study.

NCT Number	NCT07203248
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University Collaborators: First People's Hospital of Hangzhou, Sir Run Run Shaw Hospital, Affiliated Hospital of Jiaxing University, The People's Hospital of Quzhou, The First People Hospital of Hangzhou Lin An District, Shaoxing People's Hospital, Jiaxing Hospital of Traditional Chinese Medicine, Hangzhou Hospital of Traditional Chinese Medicine, Affiliated Wenling Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Second Affiliated Hospital of Wenzhou Medical University, Zhongshan Hospital Of Traditional Chinese Medicine, The First People's Hospital of Huzhou, Xin Hua Hospital of Zhejiang Province, The Affiliated Hospital of Hangzhou Normal University, Huzhou Central Hospital, Chinese Medical University, Tiantai County People's Hospital, First Affiliated Hospital of Zhejiang University
Conditions	Vestibular Migraine, Dizziness, Vertigo
Enrollment	2,000 participants
Start Date	2025-12
Primary Completion	2027-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-10-02