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A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection

Study acronym: EAT-UP
StatusRecruiting
PhasePhase 2
Started
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Record History

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  1. Eligibility criteria expanded, about 21 words
    • Secondary endpoints: details revised at 33 of 38 entries
    • Study description expanded, about 8 words
    • Site details revised at 1 of 4 sites
  2. Site details revised at 1 of 4 sitesv6
  3. Study sites: 5 to 4v5
  4. Recruitment opened
    • Start date changed from estimate of Feb 28, 2026 to Feb 26, 2026
    • Site details revised at 5 of 5 sites
    v4
  5. Study sites revised (5)v3
  6. Start date: Dec 2025 to Feb 28, 2026
    • Primary completion date: Aug 2027 to Oct 2027
    • Study completion date: Sep 2027 to Nov 2027
    • Eligibility criteria shortened, about 8 words
    v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Chronic Urinary Tract Infection (UTI) is a type of UTI where symptoms are constant and occur every day, unlike recurrent UTIs, which come and go with symptom-free breaks in between. Current treatment for chronic UTI within the NHS is based on recommended guidelines for recurrent UTI. The standard approach typically includes one of the following treatments: * Long-term, prophylactic (low) dose daily antibiotic (where medication is used at low doses to try to prevent symptoms reoccurring). * Long-term use of a urinary antiseptic (which helps keep your urine bacteria free), called methenamine hippurate. These often do not work for people with chronic UTI, and symptoms can persist. Moreover, standard urine tests may fail to detect infections, making diagnosis and treatment more challenging. The EAT-UP trial will investigate whether longer courses of treatment (higher) dose antibiotics combined with methenamine hippurate (a urinary antiseptic) are a more effective treatment at reducing levels of infection and symptoms than standard of care treatments (as described above).
Trial Details
NCT Number NCT07202949
Lead Sponsor University College, London
Conditions
(from sponsor)		 Chronic Urinary Tract Infection
Related terms Urinary Tract Infections, Urologic Diseases
Enrollment 192 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov