Effect of Early Neuromodulation Coupled With Rehabilitation on the Prevention of Post-stroke Pain

This is a prospective clinical study to evaluate the efficacy of tDCS stimulation, coupled with conventional rehabilitation, on the development of post-stroke neuropathic pain. The study involves a double-blind, randomized, sham-controlled experimental protocol involving 2 parallel groups with patients allocated according to a Fleming design (40 patients in the active group, 20 patients in the control group). The study is aimed at sub-acute post-stroke patients. After recruitment, they will receive 10 sessions of tDCS stimulation (2mA, 20 minutes with a current on/off ramp of 0.1 mA/s). For the control group, stimulation will stop after the current ramp.

NCT Number	NCT07202455
Lead Sponsor	University Hospital, Clermont-Ferrand
Conditions	Stroke, Neuropathic Pain, Central Post Stroke Pain
Enrollment	60 participants
Start Date	2026-01-01
Primary Completion	2029-04-30 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2025-12-23