Intraarticular Gold Microparticles for Knee Osteoarthritis

The investigators have shown in three pilot studies that intra-articular metallic gold microparticles can reduce knee osteoarthritis pain for up to two years. These results are noteworthy considering the growing number of older adults who suffer from osteoarthritis pain, which contributes to increased demand on healthcare resources. Demonstrating effective treatment could alleviate this burden for a significant portion of the aging population. The specific aim is to evaluate whether intra-articular metallic gold microparticles are superior to placebo in reducing the need for additional treatment in patients with knee osteoarthritis within one year. The investigators will test the hypothesis that intra-articular metallic gold microparticles reduce subsequent treatment events by more than 50% compared to placebo during this period.

NCT Number	NCT07202390
Lead Sponsor	Northern Orthopaedic Division, Denmark Collaborators: Aalborg University
Conditions	Knee Osteoarthritis
Enrollment	240 participants
Start Date	2026-02-01
Primary Completion	2026-02-01 (estimated)
Study Completion	2029-02-01 (estimated)
Updated on ClinicalTrials.gov	2025-10-01