Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications

Individuals with metabolic syndrome (MetS), particularly those with type 2 diabetes (T2D), and/or metabolic dysfunction-associated steatohepatitis or MASH face an elevated risk of major cardiovascular events (MACE). We showed decrease plams level of PPi in patients with liver cirrhosis. We hypothezised that liver transplant should block AC and restore PPi plasma level.

NCT Number	NCT07201649
Lead Sponsor	Centre Hospitalier Universitaire de Nice
Conditions	Liver Cirrhosis
Enrollment	95 participants
Start Date	2025-11-24
Primary Completion	2028-11-24 (estimated)
Study Completion	2029-11-24 (estimated)
Updated on ClinicalTrials.gov	2025-12-01