Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic Plasma

Some hemostasis techniques require spectrophotometric measurements. These are then subject to interference from the sample's lipemia (postprandial, hypertriglyceridemia, etc.), which risks distorting the results; this is estimated to affect 0.5 to 2.5% of samples. This is particularly the case for anti-Xa activity, a critical test used to monitor anticoagulant treatments. To date, the HUS Hematology Laboratory does not have or is aware of any alternative method to overcome this interference, and is unable to perform anti-Xa activity when the sample has excessive lipemia. This study will evaluate, on samples from routine care artificially overloaded with lipids, the effectiveness of a high-speed centrifugation process (10,800g for 10 minutes).

NCT Number	NCT07200674
Lead Sponsor	University Hospital, Strasbourg, France
Conditions	Hypertriglyceridemia
Enrollment	150 participants
Start Date	2024-03-11
Primary Completion	2025-12-11 (estimated)
Study Completion	2025-12-11 (estimated)
Updated on ClinicalTrials.gov	2025-10-01