Clinical Trial

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Recruiting
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Summary
This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national sample of people unmotivated to quit smoking. Participants will be randomized 2:1 to choose one of two harm-reduction products (ECIG, ONP) versus a medicinal nicotine control condition (nicotine patch + lozenge, NPL), receive a 4-week starter product regimen, and then be followed for 6 months to assess use behavior.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2030-01 -> 2030-01-31 2026-06-12
minor Completion pushed: 2030-07 -> 2030-07-31 2026-06-12
Trial Details
NCT Number NCT07199517
Lead Sponsor Abramson Cancer Center at Penn Medicine
Collaborators: National Cancer Institute (NCI), University of Pennsylvania
Conditions Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
Enrollment 472 participants
Start Date 2026-01-12
Primary Completion 2030-01-31 (estimated)
Study Completion 2030-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-11