Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis

This retrospective, observational, case-control clinical study evaluated the safety and efficacy of nasal drops containing Pistacia lentiscus oil in preventing recurrence of chronic rhinosinusitis during long-term therapy. Adult patients with chronic rhinosinusitis who received isotonic saline wash plus Pistacia lentiscus oil drops were retrospectively compared with patients who received isotonic saline wash alone, with a total treatment duration of 12 months. The primary outcome was change in Sino-Nasal Outcome Test-22 (SNOT-22) scores, while secondary outcomes included ciliary motility, nasal secretion, biofilm presence, cytological changes, adverse events, and safety/tolerability.

NCT Number	NCT07198607
Lead Sponsor	Liaquat University of Medical & Health Sciences Collaborators: Università degli Studi dell'Insubria
Conditions	Chronic Rhinosinusitis Without Nasal Polyps, Chronic Rhinosinusitis (Diagnosis)
Enrollment	100 participants
Start Date	2023-04-04
Primary Completion	2025-03-03 (estimated)
Study Completion	2025-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-14