Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

NCT Number	NCT07198308
Lead Sponsor	Shanghai Zhongshan Hospital
Conditions	Hyperglycemia
Enrollment	20 participants
Start Date	2025-10-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-03-13 (estimated)
Updated on ClinicalTrials.gov	2026-03-17