Clinical Trial

SGLT2 Inhibitor Use After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Nationwide Cohort Study

Study acronym: SGLT2i-AMI
Active, Not Recruiting
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Summary
This observational, retrospective cohort study aims to evaluate the impact of sodium-glucose cotransporter 2 (SGLT2) inhibitor use after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM). Using the nationwide database from the Korean National Health Insurance Service, the investigators will compare cardiovascular outcomes between patients treated with SGLT2 inhibitors and those treated with dipeptidyl peptidase-4 (DPP4) inhibitors after AMI. The study period includes patients diagnosed with AMI between September 2014 and June 2021, with follow-up data available through June 2022. The primary outcomes include major cardiovascular events (death, myocardial infarction, stroke) and bleeding events. This study will provide real-world evidence on the effectiveness and safety of SGLT2 inhibitors in routine clinical practice following AMI among patients with T2DM in Korea.
Trial Details
NCT Number NCT07198191
Lead Sponsor Yonsei University
Collaborators: Chong Kun Dang Pharmaceutical Corp., Health Insurance Review & Assessment Service
Conditions Acute Myocardial Infarction (AMI), Type 2 Diabetes Mellitus (T2DM)
Enrollment 200,000 participants
Start Date 2014-09-01
Primary Completion 2022-06-30 (estimated)
Study Completion 2026-08-30 (estimated)
Updated on ClinicalTrials.gov 2025-09-30