2-HOBA Supplementation in People With Elevated Lipoprotein(a)

The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels. The main questions it aims to answer are: Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood? Participants will: Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers

NCT Number	NCT07198009
Lead Sponsor	The Miriam Hospital
Conditions	Hyperlipidemia, Elevated Lp(a)
Enrollment	10 participants
Start Date	2025-11-01
Primary Completion	2026-03 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2025-09-30