Equivalent MAC in General Anesthesia

This observational study aims to evaluate the clinical applicability of the Equivalent Minimum Alveolar Concentration (eMAC) parameter during general anesthesia. eMAC is a recently developed index that combines the effects of both inhalational and intravenous anesthetics, providing a unified measure of anesthetic depth. While the traditional Minimum Alveolar Concentration (MAC) is widely used for inhalational agents, it does not reflect intravenous anesthetics or combined techniques such as Combined Intravenous and Inhalational Anesthesia (CIVIA). In this study, adult patients undergoing elective surgery under general anesthesia will be observed. Standard clinical practice will not be altered. Demographic and clinical parameters, including eMAC, MAC, Bispectral Index (BIS), and hemodynamic variables, will be recorded at defined perioperative time points. No experimental drugs or additional procedures will be administered. The primary aim is to investigate the correlation between eMAC and MAC values obtained during anesthesia. Secondary objectives include assessing the relationship between eMAC and BIS values, comparing eMAC, MAC, and BIS across different anesthetic techniques, and evaluating hemodynamic stability in relation to anesthetic depth. The results of this study may contribute to a better understanding of eMAC and its potential role in clinical anesthesia practice.

NCT Number	NCT07197567
Lead Sponsor	Sakarya University
Conditions	General Anesthesia, Intraoperative Monitoring, Anesthetic Depth
Enrollment	60 participants
Start Date	2025-11-01
Primary Completion	2026-01-15 (estimated)
Study Completion	2026-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-10