Exercise Therapy for Isotretinoin Users

Isotretinoin (13-cis retinoic acid) is a retinoic acid that is a derivative of vitamin A. Isotretinoin has been used effectively alone in acne treatment for 35 years. However, it has many side effects. Among the musculoskeletal side effects of this treatment, acute sacroileitis is a common condition. In this clinical picture, recovery may last for a few months after discontinuation of isotretinoin treatment. However, it may become permanent in some cases. According to our current knowledge, there is no study in the literature that prescribes exercise therapy for this patient group. This study, planned to investigate the effects of stretching and sacroiliac mobilization exercises on musculoskeletal pain and quality of life, which are among the side effects of isotretinoin treatment.

NCT Number	NCT07196787
Lead Sponsor	Uşak University
Conditions	Isotretinoin, Isotretinoin Adverse Reaction
Enrollment	160 participants
Start Date	2025-09-30
Primary Completion	2026-02-06 (estimated)
Study Completion	2026-03-26 (estimated)
Updated on ClinicalTrials.gov	2025-12-02