Drug-Drug Interaction of Rifampicin and Cyclosporine on Methotrexate Pharmacokinetics in Healthy Subjects

This study will evaluate how methotrexate is processed in the body when given with low doses of rifampicin or cyclosporine. These drugs may affect how methotrexate is absorbed and cleared, which could change its safety and effectiveness. Healthy volunteers will receive methotrexate with either rifampicin or cyclosporine, and blood samples will be collected to measure drug levels. The findings may help identify possible drug interactions and improve the safe use of methotrexate.

NCT Number	NCT07196449
Lead Sponsor	Seoul National University Bundang Hospital
Conditions	Drug Drug Interaction (DDI)
Enrollment	12 participants
Start Date	2025-05-14
Primary Completion	2025-06-09 (estimated)
Study Completion	2026-04-14 (estimated)
Updated on ClinicalTrials.gov	2025-09-29