Stroke of Unknown Cause in Women: The Impact of Long-term Heart Monitoring on Stroke Recurrence

The goal of this observational study is to investigate sex - differences in detection rate of atrial fibrillation after cryptogenic stroke (embolic stroke of unknown cause) - using an implantable cardiac rhythm monitor - and the treatment effects of oral anticoagulation on recurrent stroke, ischemic cardiovascular events, major bleeding risk, disability and mortality. The main questions to answer are: * Is long-term monitoring and detection of atrial fibrillation after stroke of unknown cause in women related to recurrent stroke and disability? * Is long-term monitoring and initiation of oral anticoagulation related to cardiovascular events and intracranial haemorrhages? And in addition increased in women compared to men? * Is long-term rhythm monitoring after stroke with unknown cause related to patient reported outcomes in women?

NCT Number	NCT07194811
Lead Sponsor	University Hospital, Akershus Collaborators: Haukeland University Hospital, The Dam Foundation, The Norwegian Women´s Public Health Association, University of Oslo
Conditions	Cryptogenic Stroke, Atrial Fibrillation, Implantable Cardiac Monitor, Secondary Stroke Prevention, Women's Health, Embolic Stroke of Undetermined Source, Oral Anticoagulation
Enrollment	1,400 participants
Start Date	2016-05
Primary Completion	2023-12 (estimated)
Study Completion	2025-12 (estimated)
Updated on ClinicalTrials.gov	2025-09-26