Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis

This study wishes to investigate the effects of strength exercise in patients with either HypoPP or HyperPP. The investigators wishes to include participants already diagnosed with either HypoPP or HyperPP in af 24 week prospective study where the patients will be tested and asked to fill out questionnaires three times. These appointments will be schedueled at week 0, week 12 and week 24. In the time period between week 12 and week 24, the patients will have a personalized strength exercise program, which they will have to follow these 3 months. The exercise will be supervised by one or more of the investigators. We will also assess the muscle structure and function cross sectionally.

NCT Number	NCT07194174
Lead Sponsor	Rigshospitalet, Denmark
Conditions	Hypokalemic Periodic Paralysis, Hyperkalemic Periodic Paralysis
Enrollment	36 participants
Start Date	2025-10-02
Primary Completion	2026-12-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-30