Stress Hyperglycemia Ratio and Postoperative Delirium

Postoperative delirium is a common and serious complication associated with prolonged hospitalization, increased morbidity and mortality, and elevated healthcare costs. Identifying reliable predictive biomarkers for early risk stratification is crucial for implementing preventive strategies and improving patient outcomes. The stress hyperglycemia ratio (SHR) is an emerging biomarker that quantifies stress-induced hyperglycemia relative to baseline glycemic status, providing an assessment of physiological stress. This metric has been associated with various adverse outcomes. Given that surgical stress triggers neuroendocrine and inflammatory responses potentially contributing to delirium pathogenesis, SHR may indicate vulnerability to postoperative cognitive dysfunction. The primary objective of this retrospective study is to investigate the association between preoperative stress hyperglycemia ratio and postoperative delirium development. Additionally, we aim to evaluate the predictive value of preoperative SHR for postoperative delirium risk stratification. This investigation may provide insights into metabolic stress-related mechanisms underlying postoperative cognitive outcomes and identify a clinically applicable biomarker for delirium risk assessment.

NCT Number	NCT07194096
Lead Sponsor	Rao Sun
Conditions	Postoperative Delirium
Enrollment	15,000 participants
Start Date	2025-10-15
Primary Completion	2025-11-15 (estimated)
Study Completion	2025-11-20 (estimated)
Updated on ClinicalTrials.gov	2025-09-26