Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread

The goal of this clinical trial is to learn if a combined treatment approach can treat glioblastoma (GBM) with ventricular invasion or meningeal metastasis in adults. The main questions it aims to answer are: Does the combined treatment of radical radiotherapy, the Stupp regimen (oral temozolomide), and intrathecal injection of thiotepa improve progression-free survival compared to standard treatment alone? Does the combined treatment improve overall survival compared to standard treatment alone? Participants will: * Undergo maximal surgical resection of the tumor； * Receive radical radiotherapy； * Take oral temozolomide according to the Stupp regimen； * Receive intrathecal injections of thiotepa。

NCT Number	NCT07193654
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Glioblastoma (GBM)
Enrollment	38 participants
Start Date	2025-04-01
Primary Completion	2027-04-01 (estimated)
Study Completion	2028-04-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-26