MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis

This research study is looking at new ways of measuring the function of the lungs in patients with cystic fibrosis. This study is using the most advanced methods for measuring lung function including 2 tests called hyperpolarised gas magnetic resonance imaging (HP MRI) and multiple breath washout (MBW), to better understand changes in the lungs over time. HP MRI involves taking pictures of the air in your lungs after breathing in a harmless gas (xenon). MBW is a breathing test used to calculate something called the lung clearance index (LCI). By measuring these tests on the same day, alongside standard lung function tests, we aim to understand lung function in greater detail than ever before.

NCT Number	NCT07192679
Lead Sponsor	Sheffield Teaching Hospitals NHS Foundation Trust Collaborators: University of Sheffield
Conditions	Cystic Fibrosis (CF)
Enrollment	60 participants
Start Date	2024-02-21
Primary Completion	2029-06-30 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-29