Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth

This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.

NCT Number	NCT07192289
Lead Sponsor	University of Medicine and Pharmacy at Ho Chi Minh City Collaborators: Odonto-Maxillo Facial Hospital in Ho Chi Minh City
Conditions	Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
Enrollment	57 participants
Start Date	2025-09-15
Primary Completion	2027-08-31 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-25