Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada

This is a Phase 4 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major elective, urgent, or emergent surgeries in a hospital setting. The main outcomes are to: 1. compare the efficacy, and 2. estimate the safety of applying nasal (aPDT) before surgery in reducing the incidence of SSIs within the initial 30 days after surgery compared to standard of care (SOC). Participants in the intervention group will receive aPDT prior to surgery on the day of surgery. Participants in the control group will receive standard of care surgical site prevention measures prior to surgery.

NCT Number	NCT07189858
Lead Sponsor	Ondine Biomedical Inc.
Conditions	Surgical Site Infections, Infections, Surgical Wound Infections, Anti-Infective Agents
Enrollment	401 participants
Start Date	2026-01-13
Primary Completion	2026-04-10 (estimated)
Study Completion	2026-05-10 (estimated)
Updated on ClinicalTrials.gov	2026-05-12