Prilocaine for Sphenopalatine Ganglion Block in Endoscopic Hypophysectomy

Patients undergoing endoscopic surgeries for pituitary adenoma excision suffer from wide swings in blood pressure that might increase bleeding and interfere with the surgical field. Local anethetic infiltration and regional nerve blocks have been used to provide better analgesia, control blood pressure and improve surgical field. Limited studies evaluated shenopalatine ganglion block in pituitary adenoma excision with promising outcomes. The proposed study will compare the efficacy of two local anesthetics, prilocaine and lidocaine, for spenopalatine ganglion block in patients undergoing endoscopic pituitary adenoma excision. Evaluating the control of the intraoperative blood pressure and analgesic sparing are the main objectives of the proposed study.

NCT Number	NCT07188987
Lead Sponsor	Kasr El Aini Hospital
Conditions	Blood Pressure Control
Enrollment	54 participants
Start Date	2025-12-01
Primary Completion	2026-02 (estimated)
Study Completion	2026-02 (estimated)
Updated on ClinicalTrials.gov	2025-12-05