Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation

The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main questions the study aims to answer are: * Does brain stimulation change how people behave after drinking alcohol? * Does the combination of alcohol and different types of brain stimulation affect people's ability to make thoughtful decisions or resist impulses? Researchers will compare the effects of two types of brain stimulation, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), after people drink alcohol or a placebo drink. A sham (placebo) stimulation condition will also be included. The study uses a within-person design, which means each participant will take part in all conditions. Participants will: * Attend five separate study visits * Drink either an alcoholic or placebo beverage * Receive one of the brain stimulation conditions (real or sham) * Complete decision-making tasks before and after drinking The tasks will measure things like impulsive choices and reaction time. The researchers hope this study will help identify how brain stimulation could be used to improve decision-making during intoxication, which might one day reduce harmful drinking behaviors or prevent alcohol-related accidents.

NCT Number	NCT07188376
Lead Sponsor	Michael J. Wesley, PhD
Conditions	Alcohol Risk Behaviors
Enrollment	12 participants
Start Date	2025-10-30
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-11-05