Clinical Trial

Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section

Not Yet Recruiting
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Summary
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoing elective cesarean section. Misoprostol is a prostaglandin E1 analogue that is inexpensive, heat-stable, and effective as a uterotonic agent. The study will compare outcomes between two groups: women receiving oxytocin alone and women receiving oxytocin plus rectal misoprostol. The primary outcome is the reduction of blood loss during and after surgery. Secondary outcomes include changes in hemoglobin levels, need for additional uterotonics, maternal safety, and overall recovery.
Trial Details
NCT Number NCT07188207
Lead Sponsor Assiut University
Conditions Postpartum Hemorrhage
Enrollment 282 participants
Start Date 2025-10-01
Primary Completion 2026-10-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-09-23