Clinical Trial

Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy

Completed
View on ClinicalTrials.gov →
Summary
This study is a prospective, single-center, double-blind, randomized controlled trial designed to evaluate the effect of oliceridine versus sufentanil on the incidence of hypoxemia in adult patients undergoing gastrointestinal endoscopy under deep sedation. The trial will compare the rates of hypoxemia (defined as SpO₂ ≤92%) between the two analgesic regimens when combined with propofol. The primary aim is to determine whether oliceridine can reduce the incidence of hypoxemia compared to sufentanil during endoscopic procedures.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-09-16; most recent amendment 2025-12-30.
Status change: Recruiting → Completed 2025-12-05
Status change: Not Yet Recruiting → Recruiting 2025-09-22
Trial Details
NCT Number NCT07187765
Lead Sponsor Shiyou Wei
Conditions Hypoxemia During Surgery, Gastrointestinal Endoscopy
Enrollment 508 participants
Start Date 2025-09-22
Primary Completion 2025-11-30 (estimated)
Study Completion 2025-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-01-05