Clinical Trial

Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults

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Record status
This record was last updated September 22, 2025 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty. The primary outcome is the time from sugammadex administration to recovery of a train-of-four (TOF) ratio of 0.9. Secondary outcomes include extubation time, postoperative nausea and vomiting (PONV), pain scores, complications in the post-anesthesia care unit (PACU), and intraoperative hemodynamic parameters. The study will provide new evidence on whether perioperative corticosteroid choice modifies the efficacy of sugammadex and influences postoperative recovery.
Trial Details
NCT Number NCT07187037
Lead Sponsor Konya City Hospital
Conditions Neuromuscular Block, Residual, Pain, Postoperative Nausea
Enrollment 130 participants
Start Date 2025-10-01
Primary Completion 2026-04-30 (estimated)
Study Completion 2026-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-09-22