Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is: • Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients? Participants: Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

NCT Number	NCT07185646
Lead Sponsor	Second Xiangya Hospital of Central South University
Conditions	Neuro-Oncology, MRI Imaging, Tumor Immune Microenvironment
Enrollment	200 participants
Start Date	2023-01-01
Primary Completion	2028-12-30 (estimated)
Study Completion	2030-12-30 (estimated)
Updated on ClinicalTrials.gov	2025-09-23