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Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion

Study acronym: RESCUE MeVO
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Trial status: Not Yet Recruiting to Recruitingv3 Show 5 more changesShow less
    • Start date changed from estimate of Oct 1, 2025 to Jan 6, 2026
    • Study sites: 1 to 6
    • Eligibility criteria expanded, about 19 words
    • Secondary endpoints: details revised at 3 of 6 entries
    • Study description expanded, about 4 words
  2. Re-verified, no change to tracked fieldsv2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Acute ischemic stroke (AIS) due to medium vessel occlusion (MeVO) or severe stenosis poses a significant clinical challenge. Recent large randomized controlled trials, DISTAL and ESCAPE-MeVO, demonstrated no significant benefit of endovascular therapy in patients with MeVO. Although intra-arterial thrombolysis has shown promise in clinical experience, robust evidence supporting its efficacy in MeVO or severe stenosis-related AIS is still absent. To fill this gap, the RESCUE MeVO trial has been designed as a multicenter, prospective, randomized, open-label, blinded end-point (PROBE) study to evaluate the efficacy and safety of intra-arterial thrombolysis in patients with AIS caused by MeVO or severe stenosis.
Trial Details
NCT Number NCT07185022
Lead Sponsor The Second Hospital of Anhui Medical University
Conditions
(from sponsor)		 Stroke, Cerebrovascular Disorders, Brain Diseases, Nervous System Diseases, Vascular Diseases, Ischemic Stroke, Infarction, Medium Vessel Occlusion
Related terms Brain Diseases, Cerebrovascular Disorders, Constriction, Pathologic, Infarction, Ischemic Stroke, Nervous System Diseases, Stroke, Vascular Diseases
Enrollment 282 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov