Clinical Trial

Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals

Study acronym: SCFA
Recruiting
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Summary
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively. The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-09-16; most recent amendment 2026-03-09.
Status change: Not Yet Recruiting → Recruiting 2025-11-14
Trial Details
NCT Number NCT07183488
Lead Sponsor University of Copenhagen
Conditions Healhty, Other: Short-Chain Fatty Acid (SCFA), Other: Butyrate (C4), Other: Propionate (C3)
Enrollment 10 participants
Start Date 2025-09-10
Primary Completion 2026-02-20 (estimated)
Study Completion 2030-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-10