Clinical Trial

SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children

Study acronym: Streptococcus
Recruiting
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Record status
This record was last updated November 18, 2025 (before its estimated December 15, 2025 completion). Its status may not reflect the trial's current state.
Summary
This randomized split-mouth clinical trial will compare the effectiveness of 38% silver diamine fluoride (SDF) versus 5% sodium fluoride varnish (FV) in reducing salivary Streptococcus mutans levels in children with bilateral caries. Each participant will receive SDF on one side of the mouth and FV on the contralateral side. The primary outcome is change in Dentocult SM Strip Mutans scores in plaque over 3 months. Secondary outcomes include plaque index, bleeding on probing, and adverse events.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-09-16.
Status change: Not Yet Recruiting → Recruiting 2025-11-14
Trial Details
NCT Number NCT07181967
Lead Sponsor Assiut University
Conditions Dental Caries
Enrollment 48 participants
Start Date 2025-09-15
Primary Completion 2025-12-15 (estimated)
Study Completion 2025-12-30 (estimated)
Updated on ClinicalTrials.gov 2025-11-18