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The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression

Study acronym: esketamine
StatusActive, Not Recruiting
PhasePhase 4
Started2026-05-01
View on ClinicalTrials.gov ↗

Amendment history

2026-05-06
Not Yet Recruiting→Active, Not Recruiting Study Identification, Study Status, Sponsor/Collaborators, Contacts/Locations v1
Trial statusNot Yet Recruiting→Active, Not Recruiting
Primary completion date2026-09-10→2026-11-20
Completion date2026-09-10→2026-11-20
Start dateestimated 2025-09-10→confirmed 2026-05-01
Study sites0→1
2025-09-11
Original filing
The aim of this study is to observe the antidepressant effect of low-dose esketamine in obese patients with preoperative depression and seeking bariatric surgery. We speculate that intraoperative infusion and the addition of a small dose of esketamine to the postoperative analgesic pump can help reduce the proportion of patients with depression after surgery, and may further improve postoperative recovery, reduce the use of postoperative opioids, shorten postoperative hospital stay, and improve postoperative quality of life of patients.
Trial Details
NCT Number NCT07179913
Lead Sponsor The First Hospital of Jilin University
Conditions Depressed, Bariatric Surgery
Enrollment 40 participants
Start Date 2026-05-01
Primary Completion 2026-11-20 (estimated)
Study Completion 2026-11-20 (estimated)
Updated on ClinicalTrials.gov 2026-05-08