Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation

Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC. The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA. Participants shall: Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples

NCT Number	NCT07179887
Lead Sponsor	University of Nottingham Collaborators: University of Leicester
Conditions	Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
Enrollment	45 participants
Start Date	2025-08-27
Primary Completion	2027-09-01 (estimated)
Study Completion	2027-09-30 (estimated)
Updated on ClinicalTrials.gov	2025-09-18