Time to Ambulation After ProGlide Closure

Transradial access has become the standard for coronary procedures due to fewer vascular complications and shorter bed rest, yet transfemoral access remains essential for complex peripheral interventions requiring larger sheaths and stronger support. Vascular closure devices (VCDs), particularly suture-mediated devices such as ProGlide, have improved femoral access by reducing hemostasis time, ambulation delay, and patient discomfort. Although early ambulation after ProGlide closure has been reported, current practice varies widely, and the relationship between ambulation timing and vascular complications remains unclear. This trial aims to evaluate the effect of different ambulation times after ProGlide closure in transfemoral peripheral angiography or intervention, with the goal of identifying the optimal time to ambulation that balances safety and efficiency.

NCT Number	NCT07179536
Lead Sponsor	Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions	Femoral Access Site Closure, Ambulation, Vascular Access Complication, Vascular Access Site Management
Enrollment	300 participants
Start Date	2025-10-01
Primary Completion	2026-03-30 (estimated)
Study Completion	2026-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-23